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High Flow Nasal Oxygen Therapy: From Physiology to Clinic [Eurasian J Pulmonol]
Eurasian J Pulmonol. 2017; 19(2): 54-64 | DOI: 10.5152/ejp.2017.38258  

High Flow Nasal Oxygen Therapy: From Physiology to Clinic

Fatma Yıldırım1, Serpil Öcal2, Ebru Ortaç Ersoy2, Kazım Rollas3, Burcu Başarık Aydoğan4, Turkish Respiratory Society Intensive Care Working Group5
1Surgical Intensive Care Unit, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
2Department of Internal Medicine, Internal Medicine Intensive Care Unit, Hacettepe University School of Medicine, Ankara, Turkey
3Intensive Care Unit, Zonguldak Atatürk State Hospital, Zonguldak, Turkey
4Intensive Care Unit, Denizli State Hospital, Denizli, Turkey
5Turkish Respiratory Society Intensive Care Working Group

High-flow nasal oxygen (HFNO) therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. Recently, the use of HFNO in treating adult critical illness patients has significantly increased, and it is now being used in many patients with a range of different disease conditions. However, there are no established guidelines to direct the safe and effective use of HFNO for critical patients. This review summarizes the positive physiological effects, mechanisms of action, and the clinical applications of HFNO with available published literatures.

Keywords: Critical care unit, high flow nasal oxygen, mechanisms, respiratory failure


Fatma Yıldırım, Serpil Öcal, Ebru Ortaç Ersoy, Kazım Rollas, Burcu Başarık Aydoğan, Turkish Respiratory Society Intensive Care Working Group. High Flow Nasal Oxygen Therapy: From Physiology to Clinic. Eurasian J Pulmonol. 2017; 19(2): 54-64

Corresponding Author: Fatma Yıldırım, Türkiye


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