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Ex-vivo Lung Perfusion and Its Role in Experimental Studies [Eurasian J Pulmonol]
Eurasian J Pulmonol. 2017; 19(2): 65-70 | DOI: 10.5152/ejp.2017.44366  

Ex-vivo Lung Perfusion and Its Role in Experimental Studies

Tuğba Coşgun1, Gül Dabak2, Ömer Şenbaklavacı1
1Department of Thoracic Surgery, Acıbadem University Atakent Hospital, İstanbul, Turkey
2Department of Chest Diseases, Acıbadem University Atakent Hospital, İstanbul, Turkey

Lung transplantation is an accepted treatment modality for end-stage lung diseases. However, the donor pool is not getting larger in comparison to the number of patients on the waiting list. Of the patients on the waiting list for lung transplant, more than a quarter dies while waiting. Utilization of marginal donors became an issue, and ex-vivo lung perfusion (EVLP) was started to be performed to solve this problem. Besides that, success in lung transplantation has not reached a satisfactory level for various reasons including ischemia reperfusion injury. Treatment options against these reasons that cause low success of lung transplantations are being investigated by many centers. Nowadays, EVLP that was initially developed to re-evaluate marginal donors has become a method for studies in experimental models. In our article, we want to review EVLP models in experimental studies.

Keywords: Ex-vivo lung perfusion, ischemia reperfusion injury, lung transplantation


Tuğba Coşgun, Gül Dabak, Ömer Şenbaklavacı. Ex-vivo Lung Perfusion and Its Role in Experimental Studies. Eurasian J Pulmonol. 2017; 19(2): 65-70

Corresponding Author: Tuğba Coşgun, Türkiye


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