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Immunomodulatory Effect of Exercise in Patients with Asthma [Eurasian J Pulmonol]
Eurasian J Pulmonol. 2017; 19(1): 30-33 | DOI: 10.5152/ejp.2016.86548  

Immunomodulatory Effect of Exercise in Patients with Asthma

Seda Tural Önür1, Arzu Didem Yalçın2
1Clinic of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey
2Clinic of Allergy and Clinical Immunology, Antalya Training and Research Hospital, Antalya, Turkey

Objective: Immune responses can change with exercise. We aimed to show the changes in cytokine levels pre- and post-exercise in patients with asthma.
Methods: In this prospective control trial, data of 32 patients with asthma that was under control were classified into two groups, pre- and post-exercise. Serum IL-1β and monocyte IL-1β, IL-2, and IL-10 expressions were evaluated using enzyme-linked immunosorbent assay. The patients were advised to walk for at least 30 min for 4 days/week for 12 weeks.
Results: There was no significant difference in demographic properties of the participants. Monocyte IL-1β levels in the pre- and post-exercise groups were 1.99±0.35 and 1.01±0.22 pg/mL, respectively (p=0.003). IL-10 levels in the pre- and post-exercise groups were 1.64±0.02 and 1.21±0.03 pg/mL, respectively (p=0.04). IL-2 levels in the pre- and post-exercise groups were 0.64±0.045 and 0.32±0.09 pg/mL, respectively (p=0.001). However, there was a significant difference in serum IL-1β and monocyte IL-1β, IL-2, and IL-10 levels between the groups (p=0.02, p=0.003, p=0.04, and p=0.001, respectively).
Conclusion: Systemic inflammatory parameters that are commonly elevated in asthma may improve by exercise. The elucidation of the mechanism of immune control in patients with asthma is useful for the future treatment of asthma.

Keywords: Asthma, exercise, interleukin 1β, interleukin 2, interleukin 10


Seda Tural Önür, Arzu Didem Yalçın. Immunomodulatory Effect of Exercise in Patients with Asthma. Eurasian J Pulmonol. 2017; 19(1): 30-33

Corresponding Author: Seda Tural Önür, Türkiye


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