Vinorelbine, an analogue of vinca alkaloids, has an antineoplastic effect. Adverse effects related to vinca alkaloids are rare. A 57-year-old patient who presented to the emergency room with dyspnea and back pain was hospitalized with the diagnosis of overload related to cardiac decompensation and complicated urinary tract infection due to its acute clinical and radiological findings. While under treatment, his respiratory failure progressed. Considering his history of vinorelbine usage 2 weeks prior, it was thought to be interstitial pneumonia. High-flow oxygen treatment and 250 mg/day pulse methylprednisolone for 3 days was started; after the fourth day, methylprednisolone was reduced and continued at 1 mg/kg/day. His oxygen need decreased on the seventh day of the treatment, and the findings on the chest X-ray regressed almost completely. However, the patient died due to acute gastrointestinal bleeding.