The pandemic of coronavirus disease-19 started in Wuhan City of China in December 2019 and quickly spread all over the world, infecting almost two million people. The clinical presentation of the disease is mild/moderate in 80% of cases; however, it leads to a critical clinical presentation by 20%, which is severe or very severe disease requires intensive care. The mortality is high, especially in cases with advanced age, comorbidities, and pneumonia-related acute respiratory distress syndrome and respiratory failure, while children are often with subclinical manifestations. The most common clinical findings are fever, cough, fatigue, and shortness of breath. The incubation period ranges from 2 to 14 days. The most common laboratory findings are lymphocytopenia and thrombocytopenia. Elevated D-dimer, ferritin, troponin I, lactate dehydrogenase and interleukin-6, and hypoxia (O2 saturation ≤90%) were identified as “poor prognostic factors” associated with severe disease and mortality. The monitoring of such parameters was reported to be beneficial for determining patients with risk and potentially high mortality.